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Abnormal Serum Uric Acid Levels in Health and Disease: A Double-Edged Sword

Received: 19 November 2014     Accepted: 27 November 2014     Published: 2 December 2014
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Abstract

Abnormal serum uric acid (UA) level is a highly prevalent condition worldwide and is increasing in the general population. This alarming epidemiological trend has enormous public health implications due to the central role of abnormal serum UA levels in the initiation, progression, and long-term effects of many metabolic and systemic diseases. Metabolic disorders are major causes of global morbidity and mortality. Altered serum UA level, both above and below the reference ranges for individual traits and contexts, is potentially harmful and described by many researchers as a double-edged sword. Concrete prevention plans in susceptible individuals and treatments to restore normal levels in individuals already affected are advocated. Lifestyle adjustment, including regular moderate physical activity, weight management, healthy eating, and regular serum UA screening are recommended for individuals susceptible to derangement in serum UA levels due to age, sex, genetics, and other acquired conditions. Public health efforts to create awareness about the menace of abnormal serum UA levels, particularly in susceptible individuals, should be encouraged.

Published in American Journal of Internal Medicine (Volume 2, Issue 6)
DOI 10.11648/j.ajim.20140206.15
Page(s) 113-130
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Deranged Serum Uric Acid, Adverse Health Effect, Human

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    Christopher Ekpenyong, Ernest Akpan. (2014). Abnormal Serum Uric Acid Levels in Health and Disease: A Double-Edged Sword. American Journal of Internal Medicine, 2(6), 113-130. https://doi.org/10.11648/j.ajim.20140206.15

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    ACS Style

    Christopher Ekpenyong; Ernest Akpan. Abnormal Serum Uric Acid Levels in Health and Disease: A Double-Edged Sword. Am. J. Intern. Med. 2014, 2(6), 113-130. doi: 10.11648/j.ajim.20140206.15

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    AMA Style

    Christopher Ekpenyong, Ernest Akpan. Abnormal Serum Uric Acid Levels in Health and Disease: A Double-Edged Sword. Am J Intern Med. 2014;2(6):113-130. doi: 10.11648/j.ajim.20140206.15

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  • @article{10.11648/j.ajim.20140206.15,
      author = {Christopher Ekpenyong and Ernest Akpan},
      title = {Abnormal Serum Uric Acid Levels in Health and Disease: A Double-Edged Sword},
      journal = {American Journal of Internal Medicine},
      volume = {2},
      number = {6},
      pages = {113-130},
      doi = {10.11648/j.ajim.20140206.15},
      url = {https://doi.org/10.11648/j.ajim.20140206.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20140206.15},
      abstract = {Abnormal serum uric acid (UA) level is a highly prevalent condition worldwide and is increasing in the general population. This alarming epidemiological trend has enormous public health implications due to the central role of abnormal serum UA levels in the initiation, progression, and long-term effects of many metabolic and systemic diseases. Metabolic disorders are major causes of global morbidity and mortality. Altered serum UA level, both above and below the reference ranges for individual traits and contexts, is potentially harmful and described by many researchers as a double-edged sword. Concrete prevention plans in susceptible individuals and treatments to restore normal levels in individuals already affected are advocated. Lifestyle adjustment, including regular moderate physical activity, weight management, healthy eating, and regular serum UA screening are recommended for individuals susceptible to derangement in serum UA levels due to age, sex, genetics, and other acquired conditions. Public health efforts to create awareness about the menace of abnormal serum UA levels, particularly in susceptible individuals, should be encouraged.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Abnormal Serum Uric Acid Levels in Health and Disease: A Double-Edged Sword
    AU  - Christopher Ekpenyong
    AU  - Ernest Akpan
    Y1  - 2014/12/02
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajim.20140206.15
    DO  - 10.11648/j.ajim.20140206.15
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 113
    EP  - 130
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20140206.15
    AB  - Abnormal serum uric acid (UA) level is a highly prevalent condition worldwide and is increasing in the general population. This alarming epidemiological trend has enormous public health implications due to the central role of abnormal serum UA levels in the initiation, progression, and long-term effects of many metabolic and systemic diseases. Metabolic disorders are major causes of global morbidity and mortality. Altered serum UA level, both above and below the reference ranges for individual traits and contexts, is potentially harmful and described by many researchers as a double-edged sword. Concrete prevention plans in susceptible individuals and treatments to restore normal levels in individuals already affected are advocated. Lifestyle adjustment, including regular moderate physical activity, weight management, healthy eating, and regular serum UA screening are recommended for individuals susceptible to derangement in serum UA levels due to age, sex, genetics, and other acquired conditions. Public health efforts to create awareness about the menace of abnormal serum UA levels, particularly in susceptible individuals, should be encouraged.
    VL  - 2
    IS  - 6
    ER  - 

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Author Information
  • Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria

  • Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria

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